Assoc. Prof. Luděk Bláha, Ph.D.

Assoc. Prof. Luděk Bláha, Ph.D.
  • deputy head of the Centre for Cyanobacteria and Their Toxins
  • associated professor at RECETOX, Masaryk University

Contacts:

e-mail:

Specialization:

  • analyses and ecotoxicology of cyanobacterial metabolites
  • ecotoxicology and toxicology of the aquatic environment
  • biochemical mechanisms and in vitro effects of xenobiotics including cyanotoxins

Professional:

  • Ph.D. in Environmental Chemistry (Fac. of Science, Masaryk University, Brno, 1999)
  • Habilitation/promotion - associated professor (Masaryk University, Brno, 2005)

Other activities and awards:

  • Award of the Czech Academy of Sciences (2007) for young scientists „Cyanobacterial water blooms and cyanotoxins in the Czech Republic“
  • Member of Editorial boards of Chemosphere, Environmental Science and Pollution Research
  • Member of SETAC (Society of Environmental Toxicology and Chemistry), ACS (American Chemical Society), Czech-Slovak Society of Microbiology
  • International experiences: Michigan State University, MI, USA (2004-6), National Water Research Institute, Burlington, Canada (1998)

Selected publications:

International scientific journals:

  • Novakova, K., Blaha, L., Babica, P. (2012): Tumor promoting effects of cyanobacterial extracts are potentiated by anthropogenic contaminants – evidence from in vitro study. Chemosphere 89(1): 30-37.
  • Bartova, K., Hilscherova, K., Babica, P., Marsalek, B., Blaha, L. (2011): Effects of microcystin and complex cyanobacterial samples on growth and oxidative stress paramaters in green alga Pseudokirchneriella subcapitata and comparison with the effects of model oxidative stressor, herbicide paraquat. Environmental Toxicology 26(6): 641-648.
  • Bartova, K., Hilscherova, K., Babica, P., Marsalek, B. (2011): Extract of Microcystis water bloom affects cellular differentiation in filamentous cyanobacterium Trichormus variabilis (Nostocales, Cyanobacteria). Journal of Applied Phycology 23(6): 967-973.
  • Novakova, K., Babica, P., Adamovsky, O., Blaha, L. (2011): Modulation of gap-junctional intercellular communication by a series of cyanobacterial samples from nature and laboratory cultures. Toxicon 58(1): 76-84.
  • Blahova, L., Oravec, M., Marsalek, B., Sejnohova, L., Simek, Z., Blaha, L. (2009): The first occurrence of the cyanobacterial alkaloid toxin cylindrospermopsin in the Czech Republic as determined by immunochemical and LC/MS methods. Toxicon 53(5): 519-524.
  • Haeba, M.H., Hilscherova, K., Mazurova, E., Blaha, L. (2008): Selected endocrine disrupting compounds (vinclozolin, flutamide, ketoconazole and dicofol): Effects on survival, occurrence of males, growth, molting and reproduction of Daphnia magna. Environmental Science and Pollution Research. 15(3): 222-227.
  • Blahova, L., Babica, P., Adamovsky, O., Kohoutek, J., Marsalek, B., Blaha, L. (2008): Analyses of cyanobacterial toxins (microcystins, cylindrospermopsin) in the reservoirs of the Czech Republic and evaluation of health risks. Environmental Chemistry Letters 6(4): 223-227.
  • Upham, B., Blaha, L., Babica, P., Park, J.S., Sovadinova, I., Pudrith, C., Rummel, A., Weis, L.,Sai, K., Tithof, P., Guzvic, M., Vondracek, J., Machala, M., Trosko, J. (2008): Tumor promoting properties of a cigarette smoke prevalent polycyclic aromatic hydrocarbon as indicated by the inhibition of gap junctional intercellular communication via phosphatidylcholine-specific phospholipase C. Cancer Science 99(4): 696-705.
  • Mazurova, E., Hilscherova, K., Triebskorn, R., Kohler, H.R., Marsalek, B., Blaha, L. (2008): Endocrine regulation of the reproduction in crustaceans - identification of potential targets for toxicants and environmental contaminants. Biologia 63(2): 139-150.
  • Kohoutek, J., Babica, P., Blaha, L., Marsalek, B. (2008): A novel approach for monitoring of cyanobacterial toxins - development and evaluation of the passive sampler for microcystins. Analytical and Bioanalytical Chemistry 390(4): 1167-1172.
  • Bernardova, K., Babica, P., Marsalek, B., Blaha, L. (2008): Isolation and endotoxin activities of lipopolysaccharides from cyanobacterial cultures and complex water blooms and comparison with the effects of heterotrophic bacteria and green alga. Journal of Applied Toxicology 28(1): 72-77.
  • Palikova, M., Rabova, M., Krejci, R., Navratil, S., Blaha, L. (2007): Chromosomal aberrations in early embryos of weatherfish (Misgurnus fossilis L.) exposed to crude cyanobacterial extract and semipurified compound of microcystins - a pilot study. Acta Veterinaria Brno 76(Suppl. 8): S55-S60.
  • Adamovsky, O., Kopp, R., Hilscherova, K., Babica, P., Palikova, M., Paskova, V., Navratil, S., Marsalek, B., Blaha, L. (2007): Microcystin kinetics (bioaccumulation, elimination) and biochemical responses in common carp and silver carp exposed to toxic cyanobacterial blooms. Environmental Toxicology and Chemistry 26(12): 2687-2693.
  • Blahova, L., Babica, P., Marsalkova, E., Marsalek, B., Blaha, L. (2007): Concentrations and seasonal trends of extracellular microcystins in freshwaters of the Czech Republic - results of the national monitoring program. CLEAN - Soil, Air, Water 35(4): 348-354.
  • Zounkova, R., Odraska, P., Dolezalova, L., Hilscherova K., Marsalek, B., Blaha, L. (2007): Ecotoxicity and genotoxicity assessment of cytostatic pharmaceuticals. Environmental Toxicology and Chemistry 26(10): 2208-2214.
  • Palikova, M., Krejci, R., Hilscherova, K., Buryskova, B., Babica, P., Navratil, S., Kopp, R., Blaha, L. (2007): Effects of different oxygen saturation on activity of complex biomass and aqueous crude extract of cyanobacteria during embryonal development in carp (Cyprinus carpio L.). Acta Veterinaria Brno 76(2): 291-299.
  • Novak, J., Benisek, M., Pachernik, J., Janosek, J., Sidlova, T., Kiviranta, H., Verta, M., Giesy, J.P., Blaha, L., Hilscherova, K. (2007): Interference of contaminated sediment extracts and environmental pollutants with retinoid signaling. Environmental Toxicology and Chemistry 26(8): 1591-1599.
  • Upham, B., Guzvic, M., Scott, J., Carbone, J.M., Blaha, L., Coe, C., Li, L.L., Rummel, A.M., Trosko, J.E. (2007): Inhibition of gap junctional intercellular communication and activation of mitogen-activated protein kinase by tumor-promoting organic peroxides and protection by resveratrol. Nutrition and Cancer - An International Journal 57(1): 38-47.
  • Janosek, J., Bittner, M., Hilscherova, K., Blaha, L., Giesy, J.P., Holoubek, I. (2007): AhR-mediated and antiestrogenic activity of humic substances. Chemosphere 67(6): 1096-1101.
  • Babica, P., Hilscherova, K., Bartova, K., Blaha, L., Marsalek, B. (2007): Effects of dissolved microcystins on growth of planktonic photoautotrophs. Phycologia 46(2) 137-142.
  • Palikova, M., Krejci, R., Hilscherova, K., Babica, P., Navratil, S., Kopp, R., Blaha, L. (2007): Effect of different cyanobacterial biomasses and their fractions with variable microcystin content on embryonal development of carp (Cyprinus carpio L.). Aquatic Toxicology 81(3): 312-318.
  • Buryskova, B., Hilscherova, K., Babica, P., Vrskova, D., Marsalek, B., Blaha, L. (2006): Toxicity of complex cyanobacterial samples and their fractions in Xenopus laevis embryos and the role of microcystins. Aquatic Toxicology 80(4): 346-354.
  • Buryskova, B., Hilscherova, K., Blaha, L., Marsalek, B., Holoubek, I. (2006): Toxicity and modulations of biomarkers in Xenopus laevis embryos exposed to polycyclic aromatic hydrocarbons and their N-heterocyclic derivatives. Environmental Toxicology 21(1): 590-598.
  • Smid, R., Kubasek, M., Klimes, D., Dusek, L., Jarkovsky, J., Marsalek, B., Hilscherova, K., Blaha, L., Cupr, P., Holoubek, I. (2006): Web portal for management of bioindication methods and ecotoxicological tests in ecological risk assessment. Ecotoxicology 15(8): 623-627.
  • Paskova, V., Hilscherova, K., Feldmannova, M., Blaha, L. (2006): Toxic effects and oxidative stress in higher plants exposed to polycyclic aromatic hydrocarbons and their N-heterocyclic derivatives. Environmental Toxicology and Chemistry 25(12): 3238-3245.
  • Zeisbergerova, M., Kostal, V., Sramkova, M., Babica, P., Blaha, L., Glatz, Z., Kahle, V. (2006): Separation of microcystins on monolithic electrochromatography columns. Journal of Chromatography B 841(1-2): 140-144.
  • Sovadinova, I., Blaha, L., Janosek, J., Hilscherova, K., Giesy, J.P., Jones, P.D., Holoubek, I. (2006): Cytotoxicity and Aryl hydrocarbon receptor-mediated activity of N-heterocyclic polycyclic aromatic hydrocarbons - structure-activity relationships. Environmental Toxicology and Chemistry 25(5): 1291-1297.
  • Dvorak, Z., Sovadinova, I., Blaha, L., Giesy, J.P., Ulrichova, J. (2006): Quaternary benzo[c]phenathridine alkaloids sanguinarine and chelerythrine do not affect transcriptional activity of aryl hydrocarbon receptor: Analyses in rat hepatoma cell line H4IIE.luc. Food and Chemical Toxicology 44(9): 1466-1473.
  • Babica, P., Kohoutek, J., Blaha, L., Adamovsky, O., Marsalek B. (2006): Evaluation of extraction approaches linked with ELISA and HPLC for analyses of microcystin-LR, -RR and -YR in freshwater sediments with different organic material content. Analytical and Bioanalytical Chemistry 385(8): 1545-1551.
  • Bittner, M., Janosek, J., Hilscherova, K., Giesy, J.P., Holoubek, I., Blaha, L. (2006): Activation of Ah receptor by pure humic acids. Environmental Toxicology 21(4): 338-342.
  • Feldmannova, M., Hilscherova, K., Marsalek, B., Blaha, L. (2006): Effect of N-heterocyclic polyaromatic hydrocarbons (N-PAHs) on survival, reproduction and biochemicals parameters in Daphnia magna. Environmental Toxicology 21(4): 425-431.
  • Blaha, L., Hilscherova, K., Mazurova, E., Hecker, M., Jones, P.D., Newsted, J.L., Bradley, P. W., Gracia, T., Duris, Z., Horka, I., Holoubek, I., Giesy, J.P. (2006): Alteration of steroidogenesis in H295R cells by organic sediment contaminants and relationships to other endocrine disrupting effects. Environment International 32(6): 749-757.
  • Buryskova, B., Blaha, L., Vrskova, D., Simkova, K., Marsalek, B. (2006): Sublethal toxic effects and induction of glutathione S-transferase by short chain chlorinated paraffins (SCCPs) and C-12 alkane (dodecane) in
    Xenopus laevis frog embryo. Acta Veterinaria Brno 75(1): 115-122.
  • Babica, P., Blaha, L., Marsalek, B. (2006): Exploring the natural role of microcystins - review of effects on photoautotrophic organisms. Journal of Phycology 42(1): 9-20.
  • Janosek, J., Hilscherova, K., Blaha, L., Holoubek I. (2006): Environmental xenobiotics and nuclear receptors - Interactions, effects and in vitro assessment. Toxicology In Vitro 20(1): 18-37.
  • Vlkova, M., Thon, V., Sarfyova, M., Blaha, L., Svobodnik, A., Lokaj, J., Litzman, J. (2006): Age dependency and mutual relations in T and B lymphocyte abnormalities in common variable immunodeficiency patients. Clinical and Experimental Immunology 143(2): 373-379.
  • Babica, P., Blaha, L., Marsalek, B. (2005): Removal of microcystins by phototrophic biofilms: a microcosm study. Environmental Science and Pollution Research 12(6): 369-374.
  • Vrzal, R., Zdarilova, A., Ulrichova, J., Blaha, L., Giesy, J.P., Dvorak, Z. (2005): Activation of the aryl hydrocarbon receptor by berberine in HepG2 and H4IIE cells: Biphasic effect on CYP1A1. Biochemical Pharmacology 70(6): 925-936.
  • Blaha, L., Kopp, R., Simkova, K., Mares, J. (2004): Oxidative stress biomarkers are modulated in silver carp (Hypophthalmichthys molitrix Val.) exposed to microcystin-producing cyanobacterial water bloom. Acta Veterinaria Brno 73: 477-482.
  • Vondracek, J., Chramostova, K., Pliskova, M., Blaha, L., Brack, W., Kozubik, A., Machala, M. (2004): Induction of arylhydrocarbon receptor-mediated and estrogen receptor-mediated activitites, and modulation of cell proliferation by dinaphthofurans. Environmental Toxicology and Chemistry 23(9): 2214-2220.
  • Marsalek, B., Blaha, L. (2004): Comparison of 17 biotests for detection of cyanobacterial toxicity. Environmental Toxicology 19(4): 310-317.
  • Palikova, M., Navratil, S.,  Krejci, R., Sterba, F., Tichy, F., Kubala, L., Marsalek, B., Blaha, L. (2004): Outcomes of repeated exposure of the carp (Cyprinus carpio L.) to cyanobacteria extract. Acta Veterinaria Brno 73(2): 259-265.
  • Palikova, M., Navratil, S., Tichy, F. , Sterba, F., Marsalek, B., Blaha, L.(2004): Histopathology of carp (Cyprinus carpio L.) larvae exposed to cyanobacteria extract. Acta Veterinaria Brno 73(2): 253-258.
  • Blaha, L., Sabater, S., Babica, P., Vilalta, E., Marsalek, B. (2004): Geosmin occurrence in riverine cyanobacterial mats: is it causing a significant health hazard? Water Science and Technology 49(9): 307-312.
  • Blaha, L., Klanova, J., Klan, P., Janosek, J., Skarek, M., Ruzicka, R. (2004): Toxicity increases in ice containing monochlorophenols upon photolysis: Environmental consequences. Environmental Science and Technology 38(10): 2873-2878.

Other publications:

  • Hollert, H., Duerr, M., Haag, I., Wolz, J., Hilscherova, K., Blaha, L., Gerbersdorf, S. (2007): Influence of hydrodynamics on sediment ecotoxicity. In Sediment dynamics and pollutant mobility in rivers - interdisciplinary approach, Bernhard Westrich and Ulrich Förstner (eds.). Springer-Verlag Berlin, ISBN: 978-3-540-34782-8; Heidelberg, New York, pp. 401-413.
  • Mazurova, E., Blaha, L., Hilscherova, K., Duris, Z., Horka, I., Giesy, J. P., Triebskorn, R. (2006): Ecotoxicological evaluation of sediments contaminated by waste coal by in vivo and in vitro bioassays. In Environmental Changes and Biological Assessment III (Scripta Facultatis Rerum Naturalium Universitatis Ostraviensis, vol. 163), ISBN 80-7368-201-X, pp. 274-278, pp. 187-189. Masaryk University, Brno.
  • Marsalek, B., Blaha, L., Babica, P., Adamovsky, O., Kohoutek, J., Blahova, L., Marsalkova, E., Sukacova, K., Feldmannova, M. (2006): The system for complex monitoring of toxic cyanobacteria in the Czech Republic reservoirs. In „Reservoirs - establishing the balance between human use and biotic integrity“ (Proceedings of the RESLIM 2006 - ISBN 80-86188-23-X, pp.109-112).
  • Marsalek, B., Blaha, L., Blahova, L., Babica, P. (2005): Czech Republic - Management and regulation of the cyanobacteria and cyanotoxins. In „Current approaches to cyanotoxin risk assessment, risk management and regulations in different countries“ (I. Chorus, ed.); WaBoLu ISSN 0175-4211; Federal Environmental Agency, (Umweltbundesamt), Dessau, Germany; pp. 37-39.
  • Marsalek, B., Blaha, L., Turanek, J., Neca, J. (2001): Microcystin-LR and total microcystins in cyanobacterial blooms in the Czech Republic 1993-2000. In Cyanotoxins - Occurence, Causes, Consequences (ISBN 3-540-64999-9) (I. Chorus, ed.). Springer-Verlag, Berlin, Germany. pp. 56-62.
  • Blaha, L., Marsalek, B. (2001): Dissolved microcystins in raw and treated drinking water in the Czech Republic. In Cyanotoxins - Occurence, Causes, Consequences (ISBN 3-540-64999-9) (I. Chorus, ed.). Springer-Verlag, Berlin, Germany. pp. 212-216.
  • Marsalek, B., Blaha, L. (2000): Microbiotests for cyanobacterial toxins screening. In New microbiotests for routine toxicity screening and biomonitoring (G. Persoone, C. Janssen and W. De Coen, eds.). Kluwer Academic / Plenum Publishers. pp. 519-525.


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