Research activities of the Centre for Cyanobacteria and Their Toxins (CCT)

Section of technology

Ecotoxicological characteristics of phthalocyanines and their potential usage for the reduction of mass cyanobacterial and algal development. (abstract 1, abstract 2 ) These research activities are focused on phthalocyanine toxicity towards cyanobacteria and algae including potentially non-target organisms. In addition to that, a relationship between phthalocyanine chemical structure and toxicity, an ability of singlet oxygen production as well as phthalocyanine environmental degradation and other factors have been investigated.

Algicidal and algistatic effects of natural substances. (abstract ). The research is focused on findings of environmentally-friendly possibilities for the reduction of mass cyanobacterial development. The characteristics of certain higher-plant extracts and substances isolated from them have been investigated.

Photosynthetic activity of cyanobacteria after gut passage through herbivorous fish. (abstract ). The aim of the studies is to detect changes in photosynthetic activity of cyanobacteria after the passage through fish guts and an evaluation of possible usage of herbivorous fish for the reduction of cyanobacterial development.

Possibilities for the reduction of nutrient concentrations in surface water. In laboratory and field experiments abilities of minerals, higher plants and filamentous algae to remove biologically available phosphorus (PO43-) as well as other nutrients from aquatic systems have been investigated.

Usage of aeration technologies in reduction of cyanobacterial development. In this research we have studied effects of sediment aeration on changes in physico-chemical parameters of sediments and water above sediment and changes in abundances and structure of microbial and cyanobacterial communities.

Pediastrum - SYBR Green stainingAphanizomenon - colonyDiatoma


Section of cyanotoxins

Ecotoxicology of cyanobacterial toxins. (abstract 1, abstract 2, abstract 3  ). Effects of cyanobacterial metabolites on living organisms are studied. Our recent studies focus mostly on effects in fish or birds (accumulation of toxins, modulations of biochemical and physiological markers). Further, studies on algae, i.e. cyanobacterial competitors, are studied as well (biochemical markers of toxicity, growth effects etc.)

Mechanisms of toxicity and carcinogenicity of cyanotoxins. Using in vitro toxicology tools (studies of intercellular communication, activations of nuclear receptors such as ER, AR etc.), we aim to understand principles of biochemical toxicities (mechanisms of tumor promotion).

Studies of levels and risks of microcystins and other toxins (cylindrospermopsin) (abstract 1, abstract 2 ). Using our monitoring activities in the Czech Republic (more than 80 localities), we study temporal and spatial trends in concentrations of the major cyanotoxins - microcystins. Further, we work on development and applications of highly sensitive techniques (ELISA, HPLC-MS) for detections of novel carcinogenic toxins such as cylindrospermopsin.

Passive sampling techniques for natural toxins (abstract ). We work on development of methods for continuous monitoring of toxins (e.g. at drinking water plants). Passive sampling approach allows sensitive detection of eventual peak contaminations.

Xenopus laevis - embryoMicrocystis - electron microscopyDaphnia pulex


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